Wata ƙungiyar Amurka ta gabatar da sabuwar hanyar daidaita na'urorin laser na microdisk

Wata ƙungiyar bincike ta haɗin gwiwa daga Makarantar Kiwon Lafiya ta Harvard (HMS) da Babban Asibitin MIT sun ce sun cimma nasarar daidaita fitowar na'urar laser ta microdisk ta amfani da hanyar etching ta PEC, wanda hakan ya zama sabon tushe ga nanophotonics da biomedicine "mai ban sha'awa."

(Ana iya daidaita fitowar laser microdisk ta hanyar hanyar etching PEC)

A cikin fannoninnanophotonicsda kuma maganin biomedicine, microdiskna'urorin laserkuma nanodisk lasers sun zama masu ban sha'awatushen haskeda kuma bincike. A cikin aikace-aikace da dama kamar sadarwa ta hanyar amfani da na'urar photonic, hoton bioimaging a kan-chip, fahimtar biochemical, da kuma sarrafa bayanai na quantum photon, suna buƙatar cimma fitowar laser wajen tantance tsawon rai da daidaiton madaurin kunkuntar. Duk da haka, har yanzu yana da wahala a ƙera na'urorin microdisk da nanodisk lasers na wannan madaidaicin tsawon rai a babban sikelin. Tsarin nanofabrication na yanzu yana gabatar da bazuwar diamita na diski, wanda ke sa ya yi wuya a sami tsawon rai a cikin sarrafa da samarwa na laser. Yanzu, ƙungiyar masu bincike daga Makarantar Likitanci ta Harvard da Cibiyar Wellman ta Asibitin Massachusetts donMaganin Optoelectronicta ƙirƙiro wata sabuwar dabarar yin amfani da na'urar gano ƙwayoyin cuta ta optochemical (PEC) wadda ke taimakawa wajen daidaita tsawon laser na na'urar gano ƙwayoyin cuta ta microdisk daidai da daidaiton subnanometer. An buga aikin a cikin mujallar Advanced Photonics.

Ƙirƙirar hoto
A cewar rahotanni, sabuwar hanyar da ƙungiyar ta bi ta ba da damar ƙera ƙananan na'urorin laser da nanodisk laser arrays tare da madaidaicin tsawon fitar da hayaki. Mabuɗin wannan ci gaba shine amfani da PEC etching, wanda ke ba da hanya mai inganci da sauri don daidaita tsawon hasken na'urar laser microdisc. A cikin sakamakon da ke sama, ƙungiyar ta sami nasarar samun indium Gallium arsenide phosphating microdisks da aka rufe da silica akan tsarin ginshiƙin indium phosphide. Sannan suka daidaita tsawon hasken na'urar laser na waɗannan microdisks daidai zuwa ƙimar da aka ƙayyade ta hanyar yin photochemical etching a cikin wani bayani mai narkewa na sulfuric acid.
Sun kuma yi bincike kan hanyoyin da kuma yanayin da ke tattare da takamaiman abubuwan da aka yi amfani da su wajen ƙirƙirar hotunan sinadarai (PEC). A ƙarshe, sun canja wurin jerin microdisk mai daidaita tsawon rai zuwa wani abu mai suna polydimethylsiloxane don samar da ƙwayoyin laser masu zaman kansu, waɗanda aka ware tare da raƙuman laser daban-daban. Sakamakon microdisk ɗin yana nuna bandwidth mai faɗi-faɗi na fitar da laser, tare dalaserakan ginshiƙin ƙasa da 0.6 nm da kuma ƙwayar da aka ware ƙasa da 1.5 nm.

Buɗe ƙofar zuwa aikace-aikacen biomedical
Wannan sakamakon yana buɗe ƙofa ga sabbin nanophotonics da aikace-aikacen biomedical da yawa. Misali, lasers na microdisk masu zaman kansu na iya zama barcode na physico-optical don samfuran halittu daban-daban, wanda ke ba da damar yin lakabin takamaiman nau'ikan tantanin halitta da kuma niyya ga takamaiman ƙwayoyin halitta a cikin nazarin multiplex. Ana yin lakabin takamaiman nau'in tantanin halitta ta amfani da biomarkers na gargajiya, kamar fluorophores na halitta, dige-dige na quantum, da beads masu haske, waɗanda ke da faɗi mai faɗi na layin fitarwa. Don haka, ana iya yiwa wasu takamaiman nau'ikan tantanin halitta lakabi a lokaci guda. Sabanin haka, fitar da hasken band mai kunkuntar na laser microdisk zai iya gano ƙarin nau'ikan tantanin halitta a lokaci guda.
Ƙungiyar ta gwada kuma ta yi nasarar nuna ƙwayoyin laser na microdisk da aka daidaita daidai a matsayin alamun halitta, ta amfani da su don yiwa ƙwayoyin epithelial na nono na yau da kullun lakabi MCF10A. Tare da fitar da su ta hanyar amfani da fasahar zamani mai faɗi, waɗannan lasers ɗin na iya yin juyin juya hali ga biosensing, ta amfani da dabarun biomedical da na gani da aka tabbatar kamar hoton cytodynamic, kwararar cytometry, da nazarin multi-omics. Fasahar da aka gina akan etching na PEC tana nuna babban ci gaba a cikin lasers na microdisk. Ƙarfin hanyar, da kuma daidaiton subnanometer ɗinta, yana buɗe sabbin damammaki don amfani da lasers marasa adadi a cikin nanophotonics da na'urorin biomedical, da kuma barcodes don takamaiman ƙwayoyin halitta da ƙwayoyin nazari.